Key result
A systematic review of 23 studies (76,635 patients) found no definite evidence proving the superiority of a low or high dialysate sodium concentration on hard or surrogate endpoints.
Why the study?
Does high versus low dialysate sodium concentration improve outcomes in chronic haemodialysis patients?
Systematic Review (n=76,635)
Does high versus low dialysate sodium concentration improve outcomes in chronic haemodialysis patients?
Current evidence is insufficient to recommend a uniform high or low dialysate sodium concentration for chronic hemodialysis patients, highlighting the need for adequately powered trials.
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Insufficient evidence to recommend high or low dialysate sodium in hemodialysis; leaves open optimal concentration pending powered trials.
Basile et al. (2015) conducted a systematic review in chronic haemodialysis (n=76,635). High dialysate sodium concentration vs. Low dialysate sodium concentration was evaluated on Mortality, blood pressure, interdialytic weight gain, plasma sodium, hospitalizations, use of anti-hypertensive agents and intradialytic complications. A systematic review of 23 studies (76,635 patients) found no definite evidence proving the superiority of a low or high dialysate sodium concentration on hard or surrogate endpoints.
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