Key result
Innominate artery cannulation in acute type A aortic dissection was associated with significantly lower early mortality compared to other cannulation sites (8.82% vs. 40.79%, p < 0.01).
Why the study?
The optimal arterial cannulation site in acute type A aortic dissection remains subject to debate.
Does systematic innominate artery cannulation improve mortality and perfusion indices in patients undergoing surgery for acute type A aortic dissection?
Cohort (n=110)
Does systematic innominate artery cannulation improve mortality and perfusion indices in patients undergoing surgery for acute type A aortic dissection?
Absolute Event Rate: 8.82% vs 40.79%
p-value: p=<0.01
Systematic use of the innominate artery for cannulation during acute type A aortic dissection repair significantly reduces early mortality, neurologic injury, and acute kidney injury while improving perfusion.
May support innominate cannulation to lower early mortality in acute type A dissection; leaves open need for randomized confirmation.
(1) Background: Arterial cannulation in type A acute aortic dissection (TAAAD) is still subject to debate. We describe a systematic approach of using the innominate artery for arterial perfusion (2) Methods: The hospital records of 110 consecutive patients with acute TAAAD operated on between January 2014 and December 2022 were retrospectively analyzed. The effect of the cannulation site on early and late mortality, as well as on cardio-pulmonary perfusion indices (lactate and base excess levels, and cooling and rewarming speed) were investigated. (3) Results: There was a significant difference in early mortality (8.82% vs. 40.79%, p < 0.01) but no difference in long-term survival beyond the first 30 days. Using the innominate artery enabled the use of approximately 20% higher CPB flows (2.73 ± 0.1 vs. 2.42 ± 0.06 L/min/m2 BSA, p < 0.01), which resulted in more rapid cooling (1.89 ± 0.77 vs. 3.13 ± 1.62 min/°C/m2 BSA, p < 0.01), rewarming (2.84 ± 1.36 vs. 4.22 ± 2.23, p < 0.01), lower mean base excess levels during CPB (−5.01 ± 2.99 mEq/L vs. −6.66 ± 3.37 mEq/L, p = 0.01) and lower lactate levels at the end of the procedure (4.02 ± 2.48 mmol/L vs. 6.63 ± 4.17 mmol/L, p < 0.01). Postoperative permanent neurologic insult (3.12% vs. 20%, p = 0.02) and acute kidney injury (3.12% vs. 32.81%, p < 0.01) were significantly reduced. (4) Conclusions: systematic use of the innominate artery enables better perfusion and superior results in TAAAD repair.
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Feier et al. (2023) conducted a cohort in Acute type A aortic dissection (TAAAD) (n=110). Innominate artery cannulation vs. Other cannulation sites was evaluated on Early mortality (p=<0.01). Innominate artery cannulation in acute type A aortic dissection was associated with significantly lower early mortality compared to other cannulation sites (8.82% vs. 40.79%, p < 0.01).
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