Creation of a Neonatal Thrombosis Center and its Use to Successfully Treat Infants with Severe Thromboses

Background: Clinically significant thrombosis, which can be life threatening, is a common problem in the neonatal period, affecting up to 6.8 per 1,000 neonatal intensive care admissions. These infants have increased risk for bleeding complications from anticoagulant therapy due to immature coagulation systems, concomitant infections, inflammation and coagulopathies, and CNS hemorrhage risk due to prematurity. Thus, care for these infants requires a specialized multidisciplinary team, composed of neonatologists and hematologists, along with pharmacy support.