December 1, 1999The Journal of Immunology

Extracellular Signal-Related Kinase (ERK) and p38 Mitogen-Activated Protein (MAP) Kinases Differentially Regulate the Lipopolysaccharide-Mediated Induction of Inducible Nitric Oxide Synthase and IL-12 in Macrophages: Leishmania Phosphoglycans Subvert Macrophage IL-12 Production by Targeting ERK MAP Kinase

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Population

Macrophages

Design

Preclinical

Authors

GFGui-Jie FengUniversity of Glasgow HGHelen S. GoodridgeCedars-Sinai Medical Center XWXiao-Qing WeiSouthwest Jiaotong University

Discussion

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Implication

Potential macrophage immunomodulation targets in infection; leaves open human translation from murine data.

Structured PICO

Population

Macrophages

Intervention

LPS stimulation, selective inhibitors for ERK (PD98059) and p38 (SB203580), and Leishmania lipophosphoglycans

Outcome

Induction of inducible NO synthase and IL-12 gene expression/productionsurrogate

ERK and p38 MAP kinases differentially regulate macrophage effector molecules (iNOS and IL-12), highlighting them as potential targets for therapeutic immunomodulation against intracellular pathogens.

Cite This Study

Feng et al. (1999) studied this question.

synapsesocial.com/papers/6a9813bbb588d5324d368093 https://doi.org/10.4049/jimmunol.163.12.6403

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Discussion

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Implication

Structured PICO

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Discussion

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Implication

Structured PICO

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