Response to Comment on Kolwicz et al. Enhancing Cardiac Triacylglycerol Metabolism Improves Recovery From Ischemic Stress. Diabetes 2015;64:2817–2827

In their comment, Zaugg et al. (1) highlighted some of their recent work investigating the effects of Intralipid administration on postischemic outcomes in rat models of both healthy nondiabetic (2) and early diabetic hearts (3). This was prodded by a discussion point raised in a recent article by my colleagues and I on whether the provision of a mixture of unsaturated fats, such as Intralipid, could improve functional recovery in the ischemic, diabetic myocardium (4). In their studies, Zaugg and colleagues nicely demonstrated that Intralipid infusion given during the reperfusion period improves recovery from ischemia by inhibiting …