Key result
Age, diabetes, hypertension, chronic cerebrovascular disorders, and an increasing number of medications were associated with the occurrence of brain atrophy on CT scans.
Why the study?
Are age, diabetes, hypertension, and general morbidity associated with brain atrophy on CT scans?
Observational (n=416)
No
Are age, diabetes, hypertension, and general morbidity associated with brain atrophy on CT scans?
Systemic medical disorders such as diabetes and hypertension are associated with brain atrophy, highlighting the need to consider general morbidity when assessing physiological brain aging.
Comorbidities may refine CT interpretation of brain aging beyond age alone; extends cross-sectional links but leaves open causality and clinical impact.
We evaluated, retrospectively, the occurrence of brain atrophy in all patients (n = 416) with a brain CT scan performed during a 3-month period in 1989 at the Tampere University Central Hospital. Age, diabetes, hypertension, chronic cerebrovascular disorders and an increasing number of medications were associated with brain atrophy in the log-linear models. We suggest that the effect of various systemic medical disorders on the brain requires consideration when evaluating and assessing physiological ageing of the brain.
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Pirttilä et al. (2009) conducted an observational in Brain atrophy (n=416). Age, diabetes, hypertension, chronic cerebrovascular disorders, and increasing number of medications was evaluated on Occurrence of brain atrophy. Age, diabetes, hypertension, chronic cerebrovascular disorders, and an increasing number of medications were associated with the occurrence of brain atrophy on CT scans.
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