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Synthesize polyethylene glycol-functionalized graphene oxide nanoparticles loaded with Nigella sativa extract to evaluate their physicochemical properties and antibacterial mechanism against Staphylococcus aureus and Escherichia coli.

May 21, 2021MoleculesOpen Access

Polyethylene Glycol Functionalized Graphene Oxide Nanoparticles Loaded with Nigella sativa Extract: A Smart Antibacterial Therapeutic Drug Delivery System

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Authors

MJMustafa A. JihadUniversity of Baghdad FNFarah T. M. NooriUniversity of Baghdad MJMajid S. JabirUniversity of Technology - Iraq

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Implication

In vitro study shows membrane disruption in Staphylococcus aureus and Escherichia coli, highlighting PEGylated graphene oxide loaded with Nigella sativa as an effective antibacterial delivery system.

Key Points

Synthesize polyethylene glycol-functionalized graphene oxide nanoparticles loaded with Nigella sativa extract to evaluate their physicochemical properties and antibacterial mechanism against Staphylococcus aureus and Escherichia coli.
Synthesized graphene oxide nanoparticles via Hummer's method, functionalized them with polyethylene glycol via an esterification reaction, and loaded the carrier with Nigella sativa seed extract.
Characterized structural and optical properties using X-ray diffraction, atomic force microscopy, transmission electron microscopy, Fourier-transform infrared spectroscopy, and ultraviolet-visible spectrophotometry.
Atomic force microscopy revealed graphene oxide nanoparticles with a primary grain size of 24.41 nm, expanding to aggregated structures with an average grain size of 287.04 nm following polyethylene glycol capping and Nigella sativa loading.
The functionalized nanocarrier disrupted bacterial cell wall integrity, elevated membrane permeability, and induced nucleic acid damage against Staphylococcus aureus and Escherichia coli.

Cite This Study

Jihad et al. (2021) studied this question.

synapsesocial.com/papers/6a9815e69835657fd76c7594 https://doi.org/10.3390/molecules26113067

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Implication

In vitro study shows membrane disruption in Staphylococcus aureus and Escherichia coli, highlighting PEGylated graphene oxide loaded with Nigella sativa as an effective antibacterial delivery system.

Polyethylene Glycol Functionalized Graphene Oxide Nanoparticles Loaded with Nigella sativa Extract: A Smart Antibacterial Therapeutic Drug Delivery System

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Implication

Key Points

Cite This Study

Polyethylene Glycol Functionalized Graphene Oxide Nanoparticles Loaded with Nigella sativa Extract: A Smart Antibacterial Therapeutic Drug Delivery System

Discussion

Member takes

Implication

Key Points

Cite This Study

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