Key result
Combined radiation and cytostatic treatment following surgery resulted in a survival of 40 months for a patient with a recurrent myxofibrosarcoma of the mitral valve.
Case Report (n=1)
A rare case of myxofibrosarcoma presenting as a cardiac myxoma on the mitral valve showed surprisingly long survival (40 months) following surgery, radiation, and cytostatic treatment.
May support multimodality therapy in rare cardiac sarcomas; hypothesis-generating and should not change practice.
Malignant cardiac tumours located on heart valves are very rare. We report on a myxofibrosarcoma originally presented as a cardiac myxoma (CM), partly with chondroid differentiation, located on the posterior leaflet of the mitral valve. The tumor recurred twice, the first time disguised as a CM with only minor components of myxofibrosarcoma, and finally metastazised as a myxofibrosarcoma. Patient survival (40 months from first surgery) was surprisingly long and this may well reflect both the effectiveness of the combined radiation and cytostatic treatment and the histopathological features of the tumor.
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Johansson et al. (1989) conducted a case report in Myxofibrosarcoma of the mitral valve (n=1). Combined radiation and cytostatic treatment was evaluated on Patient survival. Combined radiation and cytostatic treatment following surgery resulted in a survival of 40 months for a patient with a recurrent myxofibrosarcoma of the mitral valve.
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