The clinical epidemiology of young adults starting renal replacement therapy in the UK: presentation, management and survival using 15 years of UK Renal Registry data

Nephrol Dial Transplant 2017 gfw444. doi: 10.1093/ndt/gfw444 In the published version of this paper the Cox regression model shown in Table 3 erroneously used modality at start, rather than modality as a time dependent variable over the follow-up period as stated. The corrected version of the table is given below: Cox regression model on the effect of age group at RRT start on mortality, adjusting age group by other variables Data based on 3243 patients and 248 events and excludes those with a missing ethnicity or PRD. Glomerular disease was chosen as a comparator, as it was the most frequent diagnosis. There was a significant non-proportionality over time between those with and without diabetes, with the effect seen only after 230 days and no effect on other HRs when using a piecewise Cox regression analysis; this model presents the overall HR for the entire follow-up period. PRD codes in the ‘other systemic diseases’ group include amyloid, haemolytic uraemic syndrome, renovascular diseases and hypertension. Of those with amyloid (n = 15), 33.3% died, while the proportion of death from other conditions was 6.6, 8.6 and 6.5%, respectively. PRD codes in the ‘other tubulointerstitial disease’ group include drug-induced tubulopathies and interstitial nephritis; of those with drug-induced tubulopathies (n = 65), 32.3% died and of those with interstitial nephritis (n = 45), 15.6% died. Cox regression model on the effect of age group at RRT start on mortality, adjusting age group by other variables Data based on 3243 patients and 248 events and excludes those with a missing ethnicity or PRD. Glomerular disease was chosen as a comparator, as it was the most frequent diagnosis. There was a significant non-proportionality over time between those with and without diabetes, with the effect seen only after 230 days and no effect on other HRs when using a piecewise Cox regression analysis; this model presents the overall HR for the entire follow-up period. PRD codes in the ‘other systemic diseases’ group include amyloid, haemolytic uraemic syndrome, renovascular diseases and hypertension. Of those with amyloid (n = 15), 33.3% died, while the proportion of death from other conditions was 6.6, 8.6 and 6.5%, respectively. PRD codes in the ‘other tubulointerstitial disease’ group include drug-induced tubulopathies and interstitial nephritis; of those with drug-induced tubulopathies (n = 65), 32.3% died and of those with interstitial nephritis (n = 45), 15.6% died. Information quoted from the table in the abstract and manuscript text has been corrected. The following five sentences should read as follows: Overall 8% died, with being on dialysis and not transplant listed versus transplanted {hazard ratio [HR] 17.6 [95% confidence interval (CI) 4.36–70.9], P<0.0001} and diabetes versus glomerulonephritis [HR 4.48 (95% CI 3.05–6.58), P<0.0001] increasing mortality risk. Overall 8% died, with being on dialysis and not transplant listed versus transplanted {hazard ratio [HR] 16.6 [95% confidence interval (CI) 10.8–25.4], P<0.0001} and diabetes versus glomerulonephritis [HR 4.03 (95% CI 2.71–6.01), P<0.0001] increasing mortality risk. The strongest effect was seen with modality; being on dialysis and not listed for transplant drastically increased the risk of death compared to transplantation (HR 17.6, CI 4.36 – 70.9, p<0.0001). PRD had a major effect on survival; compared to glomerulonephritis, diabetics were nearly 5 times more likely to die (HR 4.48, CI 3.05 – 6.58, p<0.0001). Other tubulointerstitial disorders (HR 6.34, CI 3.99–10.1, p<0.0001), miscellaneous renal conditions (HR 1.81, CI 1.24–2.63, p=0.002), and other systemic diseases (HR 1.92, CI 1.07–3.44, p=0.03) also increased the risk of death. The strongest effect was seen with modality; being on dialysis and not listed for transplant drastically increased the risk of death compared to transplantation (HR 16.6, CI 10.8 – 25.4, p<0.0001). PRD had a major effect on survival; compared to glomerulonephritis, diabetics were nearly 5 times more likely to die (HR 4.03, CI 2.71 – 6.01, p<0.0001). Other tubulointerstitial disorders (HR 6.49, CI 4.07–10.4, p<0.0001), miscellaneous renal conditions (HR 1.88, CI 1.28–2.76, p=0.001), and other systemic diseases (HR 1.93, CI 1.08–3.48, p=0.03) also increased the risk of death. Despite the wide CI, the HR we present for those on dialysis and transplant listed (4.12) is similar to that of previous studies in patients <21 years of age receiving a first transplant (4.85) [25]. The HR we present for those on dialysis and transplant listed (4.2) is similar to that of previous studies in patients <21 years of age receiving a first transplant (4.85) [25]. The authors apologise for these errors.