Key result
Increasing hematocrit from 25% to 65% decreases average minimum pO2 beyond the diverging section by approximately 25% for basal flow, but increases it by approximately 15% for hyperemic flow.
Population
Computational model of a stenosed coronary artery post-angioplasty
Design
Preclinical
Authors
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Hypothesis-generating for flow-specific hematocrit effects in stenosed arteries; human validation required before any clinical consideration.
Computational modeling suggests that reducing hematocrit may improve oxygen flux in moderate stenosed arteries under basal flow, while higher hematocrit is advantageous during hyperemic flow.
Kwon et al. (2008) studied Postangioplasty residual stenosed artery. Varying hematocrit (Hct) concentrations (25% to 65%) was evaluated on Oxygen transport (pO2) in the postangioplasty residual stenosed artery. Increasing hematocrit from 25% to 65% decreases average minimum pO2 beyond the diverging section by approximately 25% for basal flow, but increases it by approximately 15% for hyperemic flow.
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