Changes in Skeletal Muscle after Discontinuation of Growth Hormone Treatment in Young Adults with Hypopituitarism

Rutherford, O.M., Jones, D.A., Round, J.M. and Preece, M. (Department of Medicine, Rayne Institute, University College and Middlesex School of Medicine; and the Department of Growth and Development, Institute of Child Health, Great Ormond Street, London, UK). Changes in skeletal muscle after discontinuation of growth hormone treatment in young adults with hypopituitarism. Acta Paediatr Scand [Suppl] 356: 61, 1989. Skeletal muscle strength and size were measured for 1 year following discontinuation of human growth hormone (hGH) treatment in 11 patients with hypopituitarism. Quadriceps and forearm flexor maximum voluntary isometric strength and size were measured. At the end of the study, endocrine status was reassessed by an insulin tolerance test. Three of the 11 subjects were found to have normal hGH secretion and were not included in the analysis. At 12 months, quadriceps strength, size and fibre areas were 94.0 ± 8.5%, 94.5 ± 6.3% and 85.6 ± 17.7% (mean ± SD), respectively, of baseline values. Forearm flexor strength and size were 101.4 ± 7.9% and 92 ± 9.2% of control values. Although these changes are relatively small, they suggest a role for growth hormone in the maintenance of muscle in the adult.