Why the study?
Does co-administration of lansoprazole or pantoprazole alter the steady-state pharmacokinetics of theophylline in healthy males?
Population
30 healthy, non-smoking males
Comparison
Theophylline 200 mg extended-release twice daily… vs Theophylline alone within the same subjects
Design
Other
Follow-up
11 days
Authors
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Supports no theophylline dose adjustment with these PPIs; leaves open validation in patients with comorbidities.
Does co-administration of lansoprazole or pantoprazole alter the steady-state pharmacokinetics of theophylline in healthy males?
Co-administration of lansoprazole or pantoprazole does not significantly affect the steady-state pharmacokinetics of theophylline.
Pan et al. (2000) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: