Key result
EHD1-4 proteins associate with ankyrin in cardiomyocytes, and EHD3 deficiency leads to aberrant ankyrin-B localization and loss of Na/Ca exchanger expression and function.
Authors
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Does not alter clinical management; leaves open EHD3's therapeutic relevance in human arrhythmia or cardiomyopathy.
Gudmundsson et al. (2010) studied Cardiovascular disease. EHD3 deficiency vs. Wild-type/normal expression was evaluated on Membrane protein targeting and ankyrin-B localization. EHD1-4 proteins associate with ankyrin in cardiomyocytes, and EHD3 deficiency leads to aberrant ankyrin-B localization and loss of Na/Ca exchanger expression and function.
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