Key result
Prednisolone was effective in preventing multivessel coronary artery spasm that was refractory to intensive medical treatment with multiple vasodilators.
Prednisolone may be effective in preventing multivessel coronary artery spasm that is refractory to intensive vasodilator therapy.
May support prednisolone trial in refractory multivessel spasm; hypothesis-generating and requires prospective validation before practice change.
This case report describes multivessel coronary artery spasm refractory to oral nifedipine, intravenous isosorbide dinitrate, diltiazem and nicorandil, and intracoronary nitroglycerin. Intracoronary administration of nicorandil only transiently relieved coronary artery spasm. Prednisolone was effective in preventing coronary artery spasm.
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Asano et al. (2007) studied this question. Prednisolone was effective in preventing multivessel coronary artery spasm that was refractory to intensive medical treatment with multiple vasodilators.
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