Why the study?
Does intracoronary administration of nicorandil relieve coronary spasm refractory to nitroglycerin in patients undergoing catheterization?
Does intracoronary administration of nicorandil relieve coronary spasm refractory to nitroglycerin in patients undergoing catheterization?
Intracoronary nicorandil may be a useful therapeutic agent for coronary spasm refractory to nitroglycerin.
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May offer bailout option for refractory spasm; Level 5 case report leaves open need for trials.
Two patients in whom coronary spasm was refractory to intracoronary injection of nitroglycerin were relieved by intracoronary administration of nicorandil (a nitrate and potassium channel opener) during catheterization. These findings suggest that nicorandil may prove useful as an additional therapeutic agent.
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Noguchi et al. (2000) studied this question.
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