Population
Patients with symptomatic coronary artery disease (stable and vasospastic angina pectoris) and animal models
Comparison
Nicorandil vs Placebo and active comparators
Design
Review
Authors
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May support nicorandil for angina without tolerance concerns; leaves open need for confirmatory RCTs.
Nicorandil is an effective oral potassium channel opener for treating stable and vasospastic angina without causing tolerance, though its short duration of action requires extended-release formulations.
Goldschmidt et al. (1996) studied this question.
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