Key result
Diuretic and oral hypoglycemic use were significant positive predictors of hydration status in 169 patients with CKD and hypertension, while female sex and higher BMI were negative predictors.
Why the study?
To determine body fluid volume and examine the relationship between fluid overload, nutritional status, and arterial stiffness in patients diagnosed with both CKD and arterial hypertension.
Cross-Sectional (n=169)
In patients with CKD and hypertension, volume status is associated with arterial stiffness and is influenced by medication use, sex, and BMI, highlighting the need for volume status awareness, especially in those with diabetes.
May guide volume assessment in CKD hypertension; leaves open causal confirmation and outcome trials.
The aim of this cross-sectional study was to determine the body fluid volume in patients diagnosed with both chronic kidney disease (CKD) and arterial hypertension (AH), and to investigate the relationship between fluid overload (FO), nutritional status and arterial stiffness in this specific patient population. A total of 169 participants with CKD and AH were enrolled in the study, and data on general parameters, comorbidities, medication use, and laboratory parameters were collected. Body composition was assessed with a Tanita MC 780 device, and data on the central and peripheral systolic and diastolic blood pressure, as well as pulse wave velocity (PWV) and the augmentation index (AIx) were collected with an IEM Mobil-O-Graph 24 h ambulatory blood pressure monitor, which was based on oscillometry. The Mediterranean Diet Serving Score (MDSS) questionnaire was used to determine the adherence to the Mediterranean diet (MeDi). Our results showed that the significant positive predictors of hydration status were the use of diuretics and oral hypoglycemic agents, whereas the negative predictors were female sex, higher body mass index level and use of two or more antihypertensives in the form of a single-pill combination. We also found differences in blood pressure and arterial stiffness parameters in relation to volume status, along with differences based on the presence of diabetes mellitus (DM). In conclusion, these results call for a higher awareness of volume status in the care of CKD patients with AH, especially in those with diabetes mellitus.
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Radić et al. (2023) conducted a cross-sectional in Chronic kidney disease (CKD) and arterial hypertension (AH) (n=169). Fluid overload and nutritional status was evaluated on Predictors of hydration status and differences in blood pressure and arterial stiffness parameters. Diuretic and oral hypoglycemic use were significant positive predictors of hydration status in 169 patients with CKD and hypertension, while female sex and higher BMI were negative predictors.
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