A patient with cadmium poisoning may show disturbances in liver, kidney, and bone marrow function as well as the classic pulmonary symptoms. In addition there may be marked mental irritability. Cadmium intoxication was treated successfully with the oral administration of edathamil calcium disodium. The mechanism of the process is replacement of the calcium ion in the chelating agent by a cadmium ion and the excretion of the chelate in a nonirritating form through the kidneys. There were no unpleasant sidereactions encountered in these patients, and oral administration of the drug proved effective.
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Lawrence H. Cotter (1958) studied this question.