All articles of this category The organozinc reagent 3 reacts with unfunctionalised acid chlorides under palladium catalysis to give enantiomerically pure protected 5-oxo amino acids in good to excellent yields, provided dimethoxyethane (DME) is used as solvent. For functionalised acid chlorides, the solvent systems benzene/dimethylacetamide (DMA) or toluene/DMA are preferred. α-amino acids - organozinc reagents - palladium catalysed cross-coupling - 5-oxo amino acids
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Fraser et al. (1995) studied this question.