Key result
Hypoxia (1% oxygen) stimulated epithelial-to-mesenchymal transition and enhanced expression of vascular smooth muscle cell markers in mouse epicardial cell cultures via the TGFβ pathway.
Population
Mouse epicardial cell cultures
Design
Preclinical
Authors
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Does not support clinical translation; leaves open epicardial TGFβ roles in human coronary vasculogenesis.
Hypoxia promotes the differentiation of epicardial cells into vascular smooth muscle cells via noncanonical TGFβ signaling, elucidating a mechanism for coronary vasculogenesis.
Tao et al. (2018) studied this question. Hypoxia was evaluated on Epicardium-derived cell (EPDC) differentiation into vascular smooth muscle cells (VSMCs). Hypoxia (1% oxygen) stimulated epithelial-to-mesenchymal transition and enhanced expression of vascular smooth muscle cell markers in mouse epicardial cell cultures via the TGFβ pathway.
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