Key result
In patients with burning mouth syndrome, an increased LF/HF ratio was significantly associated with a decreased probability of pain improvement after treatment (OR 0.515).
Why the study?
The study aimed to identify heart rate variability characteristics in burning mouth syndrome and evaluate its predictive value for Korean medical treatment responsiveness to tongue pain.
Does heart rate variability correlate with clinical characteristics and predict treatment response in patients with burning mouth syndrome?
Cross-Sectional (n=217)
No
Does heart rate variability correlate with clinical characteristics and predict treatment response in patients with burning mouth syndrome?
In patients with burning mouth syndrome, autonomic nerve activity is generally reduced, and baseline autonomic imbalance (higher LF/HF ratio) predicts a poorer response to pain treatment.
Objectives: This study aimed to identify the characteristics of the heart rate variability (HRV) index in patients with burning mouth syndrome (BMS) and to evaluate the predictive value of HRV for Korean medical treatment responsiveness to tongue pain in BMS.Methods: Among BMS patients who visited the Oral Diseases Clinic of Kyung Hee University Korean Medicine Hospital from January 1, 2018, to May 31, 2021, we reviewed the clinical records of 217 women aged 50 years and over. HRV and unstimulated saliva flow rate (USFR) measurements were carried out, and all patients were asked to indicate their degree of tongue pain using the visual analog scale (VAS). The subjects were classified into subgroups according to the presence or absence of hyposalivation and VAS improvement, and each subgroup was compared using the HRV index. Logistic regression analysis was conducted to confirm whether cause–effect relationships were present between statistically significant values.Results: BMS patients had lower LF and HF than healthy people. Subgroup analysis demonstrated that there were some statistically significant differences in the HRV index according to salivation rate and degree of pain. In addition, as the LF/HF ratio increased, the pain improvement rate decreased after treatment.Conclusion: The autonomic nerve activity of BMS patients was lower than that of healthy people; however, autonomic balance was not impaired. In addition, tongue pain in BMS patients responded more favorably to Korean medical treatment when patients fell within a normal range of the LF/HF ratio, suggesting that autonomic imbalance could be used as one of the predictable factors in clinical practice.
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Lee et al. (2022) conducted a cross-sectional in Burning Mouth Syndrome (n=217). Increased LF/HF ratio vs. Lower LF/HF ratio was evaluated on Pain improvement (VAS reduction) after treatment (OR 0.515, 95% CI 0.295-0.900, p=0.020). In patients with burning mouth syndrome, an increased LF/HF ratio was significantly associated with a decreased probability of pain improvement after treatment (OR 0.515).
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