June 1, 1995European Journal of Neuroscience
Truncated and Catalytic Isoforms of trkB are Co‐expressed in Neurons of Rat and Mouse CNS
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Discussion
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Implication
Expression analysis demonstrates co-expression of truncated and catalytic TrkB isoforms in rodent neurons, suggesting truncated receptors modulate neurotrophin signaling.
Key Points
- Determine the anatomical distribution and developmental expression patterns of truncated (T1trkB and T2trkB) versus catalytic (TK+trkB) TrkB receptor mRNA isoforms in the rodent central nervous system.
- Mapped the localization of mRNA encoding truncated (T1trkB, T2trkB) and catalytic (TK+trkB) isoforms in adult rat and mouse central nervous system tissues.
- Analyzed developmental changes in TrkB isoform hybridization within the rodent spinal cord ventral horn across different ages.
- Both T1trkB and T2trkB transcripts co-express with catalytic TK+trkB in adult motor neurons, with T2trkB expression restricted to neurons while T1trkB is prominent in non-neuronal cells.
- Hybridization signals for truncated TrkB isoforms display a progressive, age-related increase in the developing spinal cord ventral horn.
Cite This Study
Armanini et al. (1995) studied this question.