Hypseudohenrins I − K: three new polycyclic polyprenylated acylphloroglucinol derivatives fromHypericum pseudohenryi

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Three previously unidentified polycyclic polyprenylated acylphloroglucinols (PPAPs) derivatives, hypseudohenrins I–K (1–3), along with a known analogue hyphenrone X (4), were isolated from the aerial part of Hypericum pseudohenryi. The structures of the new compounds were elucidated by NMR spectroscopy and ECD calculation. The anti-inflammatory activity of the compounds was evaluated. Compounds 1–3 showed mild anti-inflammatory activity while hyphenrone X showed prominent anti-inflammatory activity.