Why the study?
Are circulating apelin and IGF-1 concentrations linked with retinopathy of prematurity in preterm babies?
Are circulating apelin and IGF-1 concentrations linked with retinopathy of prematurity in preterm babies?
Variations in apelin and IGF-1 levels are correlated and may be linked to the pathogenesis of retinopathy of prematurity.
Apelin-IGF-1 correlation in preterm infants is hypothesis-generating for ROP pathogenesis; requires prospective validation before any clinical consideration.
AIM: We hypothesized that circulating apelin concentrations in preterm babies might be linked with retinopathy of prematurity (ROP), similar to IGF-1 levels. PATIENTS & METHODS: A total of 97 infants born with a gestational age before 32 weeks in 2007-2009 were screened for ROP at the Gata Haydarpasa Hospital (Turkey). Fourteen of them with classified ROP stage 3-5 comprised our study group. RESULTS: The non-ROP group had higher apelin and IGF-1 levels than ROP neonates at birth. After 4-6 weeks, postnatal ROP subjects had lower apelin and IGF-1 levels than non-ROP controls. At the end of the study, the change in apelin levels was positively correlated with the change in IGF-1 levels (r = 0.852; p = 0.01). CONCLUSION: We suggested that the pathogenesis of ROP, which is regarded as a neovascular retinal disorder, includes variations in the levels of apelin and IGF-1.
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Çekmez et al. (2012) studied this question.
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