Key result
Gene polymorphisms in AGT, ACE, NOS3, TNF, MMP9, and CYBA are associated with cardiovascular diseases via RAAS activation, nitric oxide decline, chronic inflammation, and oxidative stress.
This review summarizes key gene polymorphisms linked to cardiovascular disease pathogenesis via various molecular pathways.
Hypothesis-generating for genetic CVD pathways; prospective trials needed before any clinical application.
In this research we examined studies of gene polymorphisms, associated with cardiovascular diseases through renin-angiotensin-aldosterone system activation (AGTс.521С>Т,AСEIns>Del), nitric oxide decline (NOS3с.894G>T), chronic inflammation (TNF-238G>A,MMP9-1562С>T) and oxidative stress (CYBAc.214Т>С).
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Akopyan et al. (2021) studied this question. Gene polymorphisms in AGT, ACE, NOS3, TNF, MMP9, and CYBA are associated with cardiovascular diseases via RAAS activation, nitric oxide decline, chronic inflammation, and oxidative stress.
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