Key result
TNF -238G>A, MMP9 -1562С>T, and CYBA c.214Т>С polymorphisms were not significantly associated with subclinical arterial wall changes in healthy adults.
Why the study?
There is limited evidence on the influence of genotypes correlated with chronic inflammation and oxidative stress on subclinical arterial wall changes and cardiovascular disease risk factors.
Do TNF, MMP9, and CYBA polymorphisms associate with subclinical arterial wall changes and cardiovascular disease risk factors in healthy people?
Cross-Sectional (n=160)
No
Do TNF, MMP9, and CYBA polymorphisms associate with subclinical arterial wall changes and cardiovascular disease risk factors in healthy people?
Specific genetic polymorphisms in TNF, MMP9, and CYBA are associated with metabolic risk factors and telomere length, but not with subclinical arterial wall changes in healthy individuals.
No association with subclinical arterial changes warrants no practice change; leaves open metabolic and telomere links in larger studies.
Chronic inflammation and oxidative stress play key role in arterial wall changes and cardiovascular diseases. There is limited evidence on influence of genotypes, which are correlated with dironic inflammation and oxidative stress at arterial wall changes (pulse wave velocity, carotid artery intima-media thickness, endothelium-dependent vasodilation, presence of atherosclerotic plaques) and risk factors of cardiovascular diseases. We examined association of TNF-238G>A polymorphism, MMP9 -1562C>T polymorphism, CYBA c.214Т>С polymorphism with arterial wall changes and risk factors of cardiovascular diseases in 160 healthy people of different ages. GG genotype of TNF -238G>A polymorphism was associated with lower levels of aldosterone (p=0,021), higher levels of glycated haemoglobin (p=0,02) and insulin-like growth factor (p=0,032). СТ genotype of MMP9 -1562C>T polymorphism was associated with most commonly found obesity (p=0,05). CC and TC genotypes of CYBA c.214Т>С polymorphism were associated with shorter leucocyte telomere length (p=0,011). There wasn't found any association of TNF, MMP9, CYBA polymorphism with arterial wall changes. Association was found between TNF -238G>A polymorphism and MMP9 -1562C>T polymorphism with metabolic parameters, CYBA c.214Т>С polymorphism with leucocyte telomere length.
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Akopyan et al. (2020) conducted a cross-sectional in Healthy adults (n=160). TNF -238G>A, MMP9 -1562С>T, and CYBA c.214Т>С polymorphisms vs. Reference genotypes was evaluated on Subclinical arterial wall changes (pulse wave velocity, intima-media thickness, endothelium-dependent vasodilation, atherosclerotic plaques). TNF -238G>A, MMP9 -1562С>T, and CYBA c.214Т>С polymorphisms were not significantly associated with subclinical arterial wall changes in healthy adults.
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