Key result
The TNF-α-308 AA genotype was associated with a higher risk of coronary artery disease with ≥50% stenosis (OR 3.56; 95% CI 1.02-12.41; P=0.046).
Why the study?
Does the TNF-α-308 G/A gene polymorphism increase the risk of coronary artery disease?
Case-Control (n=903)
Does the TNF-α-308 G/A gene polymorphism increase the risk of coronary artery disease?
Odds Ratio: 3.56 (95% CI 1.02–12.41)
p-value: p=0.046
The TNF-α-308 AA genotype is associated with a significantly higher risk of obstructive coronary artery disease and correlates with elevated blood pressure and CRP levels.
TNF-α 308 AA genotype was associated with higher CAD risk; leaves open prospective validation before any role in risk stratification.
BACKGROUND: Coronary artery disease (CAD) is the leading cause of death worldwide and remains a major health problem, providing the rationale for identification of molecular markers for detection of individuals at high risk of developing CAD. Tumor necrosis factor-α (TNF-α) plays a crucial role in the pathogenesis of CAD. We have therefore explored the association of TNF-α 308 (G/A) gene polymorphism in 903 individuals with/without CAD. METHODS: TNF-α 308 gene polymorphism was analyzed in 903 subjects of whom 222 were healthy controls. Among the 681 patients who were investigated angiographically, 468 had ≧50% stenosis and 213 patients had <50% stenosis. Biochemical profiles (eg, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, fasting blood glucose, and CRP) were evaluated. Associations between TNF-α genotypes with biochemical and anthropometric characteristics were determined. RESULTS: The frequencies of TNF-α-AA or AG genotypes were significantly lower in patients classified as CAD patients with ≥ or <50% obstruction in at least one coronary artery, compared to the control group. We observed that CAD patients with ≥50% stenosis and with AA genotype were associated with higher risk of CAD with OR of 3.56 (95%CI: 1.02-12.41; P=.046) using multivariate analysis. Moreover, we found that TNF-α-308-AA genotype was associated with blood pressure and CRP level in CAD patients, compared to the wild type-genotype. CONCLUSION: Our data showed an association of TNF-α-308G/A polymorphism with CAD patients with ≥50% obstruction, supporting the need for further investigations on the role of TNF-α-308G/A polymorphism with hypertension.
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Kazemi et al. (2017) conducted a case-control in Coronary artery disease (n=903). TNF-α 308 (G/A) gene polymorphism (AA genotype) vs. Wild type-genotype / healthy controls was evaluated on Risk of CAD with ≥50% stenosis (OR 3.56, 95% CI 1.02-12.41, p=0.046). The TNF-α-308 AA genotype was associated with a higher risk of coronary artery disease with ≥50% stenosis (OR 3.56; 95% CI 1.02-12.41; P=0.046).
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