Key result
The TNF-α rs1800629 polymorphism was associated with a significantly increased susceptibility to dilated cardiomyopathy under the dominant model (OR 1.87).
Why the study?
The role of the TNF-alpha gene -308G/A (rs1800629) polymorphism in DCM pathogenesis remained controversial across different populations.
Does the rs1800629 polymorphism in the TNF-α gene increase susceptibility to dilated cardiomyopathy?
Meta-Analysis (n=3,016)
Does the rs1800629 polymorphism in the TNF-α gene increase susceptibility to dilated cardiomyopathy?
Odds Ratio: 1.87 (95% CI 1.01–3.45)
p-value: p=0.046
The TNF-α rs1800629 polymorphism is moderately associated with increased susceptibility to dilated cardiomyopathy, particularly in Asian populations.
OBJECTIVE: Several published studies have investigated the association between the -308G/A (rs1800629) polymorphism in the tumor necrosis factor-α (TNF-α) gene and the risk of dilated cardiomyopathy (DCM). However, the TNF-α gene polymorphism has a controversial role in the pathogenesis of DCM among different populations. In the present study, a meta-analysis was performed to resolve this inconsistency. METHODS: Potentially eligible papers reporting an association between the TNF-α rs1800629 polymorphism and DCM susceptibility were searched in 4 databases including PubMed, EMBASE, Chinese Biomedical Database (CBM), and the Cochrane Library up to April 1, 2018. The odds ratio (OR) with its 95% confidence interval (CI) was used to estimate the strength of the associations. Subgroup analysis based on the ethnicity, studies with or without ischemic and valvular DCM was conducted. Publication bias detection was conducted using Begg test. RESULTS: Nine papers detailing case-control studies were included, reporting a total of 1339 DCM cases and 1677 healthy controls. The meta-analysis results indicated that TNF-α rs1800629 was associated with increased DCM susceptibility in the populations studied under the heterozygous model (AG vs GG: OR = 1.91, 95% CI = 1.05-3.50, P = .035) and dominant model (AG + AA vs GG: OR = 1.87, 95% CI = 1.01-3.45, P = .046). In the subgroup analysis for ethnicity, rs1800629 polymorphism was significantly associated with the susceptibility of DCM for Asians under the 5 models (A vs G: OR = 2.87, 95% CI = 1.56-5.30, P = .001; AA vs GG: OR = 3.95, 95% CI = 1.13-13.82, P = 0.031; AG vs GG: OR = 3.8, 95% CI = 1.57-9.19, P = .003; AA vs GG + AG: OR = 2.51, 95% CI = 1.41-4.49, P = .002; AG + AA vs GG: OR = 3.77, 95% CI = 1.54-9.20, P = .004). CONCLUSION: There may be a moderate association between TNF-α rs1800629 polymorphism and DCM susceptibility in the whole populations studied; however, TNF-α rs1800629 polymorphism was significantly associated with the susceptibility of DCM for Asians, which indicates that such associations may be different between ethnicities.
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Zhang et al. (2018) conducted a meta-analysis in Dilated cardiomyopathy (n=3,016). TNF-α rs1800629 polymorphism vs. Wild-type genotype (GG) was evaluated on Dilated cardiomyopathy susceptibility (dominant model AG + AA vs GG) (OR 1.87, 95% CI 1.01-3.45, p=0.046). The TNF-α rs1800629 polymorphism was associated with a significantly increased susceptibility to dilated cardiomyopathy under the dominant model (OR 1.87).
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