Key result
The GA/AA genotypes of TNF-α (308) were significantly associated with an increased risk of dilated cardiomyopathy compared with the GG genotype (OR 1.92; 95% CI 1.05-3.52).
Why the study?
Are single-nucleotide polymorphisms of the TNF gene associated with increased susceptibility to dilated cardiomyopathy in a Han Chinese population?
Population
110 patients with dilated cardiomyopathy (DCM) and 110 control subjects from a Han Chinese population
Comparison
Presence of single-nucleotide polymorphisms of… vs Absence of these polymorphisms and healthy…
Design
Case-control
Authors
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TNF-α (308) GA/AA genotypes may raise dilated cardiomyopathy risk in Han Chinese; hypothesis-generating and should not yet change practice.
Case-Control (n=220)
Are single-nucleotide polymorphisms of the TNF gene associated with increased susceptibility to dilated cardiomyopathy in a Han Chinese population?
Odds Ratio: 1.92 (95% CI 1.05–3.52)
Polymorphisms in the TNF gene, specifically TNF-α (308) and TNF-ß (+252), are associated with an increased risk of dilated cardiomyopathy in the Han Chinese population.
Liang et al. (2010) conducted a case-control in Dilated cardiomyopathy (n=220). TNF-α (308) GA/AA genotype vs. GG genotype was evaluated on Dilated cardiomyopathy (OR 1.92, 95% CI 1.05-3.52). The GA/AA genotypes of TNF-α (308) were significantly associated with an increased risk of dilated cardiomyopathy compared with the GG genotype (OR 1.92; 95% CI 1.05-3.52).
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