Hepatitis B Virus Vaccine

Letters and Corrections1 September 1982Hepatitis B Virus VaccineARLENE A. MCLEAN, PH.D., RAYMOND SHAW JR., PH.D.ARLENE A. MCLEAN, PH.D., RAYMOND SHAW JR., PH.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-3-451_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The paper by Francis and associates (1) in this issue shows the safety and efficacy of inactivated hepatitis B vaccine in a large multi-center trial. A disturbing finding is the lower than expected immunogenicity of the vaccine. Factors that could affect the potency of the vaccine were carefully examined. The purpose of this letter is to summarize those findings.Our investigations centered on the shipment and storage conditions of the vaccine, for three reasons. First, it has been shown that male homosexuals respond well to 20-µg doses of vaccine (SZMUNESSW, STEVENSCE. Personal communication). Second, vaccine...References1. FRANCISHADLERTHOMPSON DSS. The prevention of hepatitis B with vaccine: report of the Centers for Disease Control multi-center trial among homosexual men. Ann Intern Med. 1982;97:362-6. LinkGoogle Scholar2. KRUGMANHOLLEYDAVIDSONSIMBERKOFFMATSANIOTIS SHMMN. Immunogenetic effect of inactivated hepatitis B vaccine: comparison of 20 µg and 40 µg doses. J Med Virol. 1981;8:119-21. CrossrefMedlineGoogle Scholar3. SZMUNESSSTEVENSHARLEY WCE. The immune response of healthy adults to a reduced dose of hepatitis B vaccine. J Med Virol. 1981;8:123-9. CrossrefMedlineGoogle Scholar4. . Expanded programme on immunization: the effects of freezing on the appearance, potency and toxicity of adsorbed and unadsorbed DPT vaccines. Weekly Epidemiologic Record. 1980;50:385-92. Google Scholar5. . Expanded programme on immunization: the effects of freezing on the appearance, potency and toxicity of adsorbed and unadsorbed DPT vaccines. Weekly Epidemiologic Record. 1980;51:396-8. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Merck Sharp & Dohme; West Point, PA 19486 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHepatitis B VaccinesThe effect of cool water pack preparation on vaccine vial temperatures in refrigeratorsAdvances in aluminum hydroxide-based adjuvant research and its mechanismHepatitis B vaccinesMethodologic reporting requirements for clinical trials: Advancing the science today and tomorrowHepatitis B vaccinesNear-critical fluid micronization of stabilized vaccines, antibiotics and anti-viralsFreezing temperatures in the vaccine cold chain: A systematic literature reviewExposure to heat and freezing in the vaccine cold chain in ThailandImmunogenicity of combined hepatitis A and B vaccine in elderly personsElectronic temperature monitoring and feedback to correct adverse vaccine storage in general practiceResponse to supplementary vaccination with recombinant or plasma hepatitis B vaccine in healthy non-responding childrenFactors influencing the immune response to hepatitis B vaccine, booster dose guidelines, and vaccine protocol recommendationsEffect of timing of hepatitis B vaccine doses on response to vaccine in Yucpa IndiansAntibody to Human Immunodeficiency Virus (HIV) and Suboptimal Response to Hepatitis B VaccinationAnn C. Collier, MD, Lawrence Corey, MD, Victory L. Murphy, CRN, H. Hunter Handsfield, MDHepatitis B Prevention and Human Immunodeficiency Virus (HIV) InfectionStephen C. Hadler, MDPoor response to hepatitis B vaccine administered to Aboriginal infants in Central AustraliaLong-Term Immunogenicity and Efficacy of Hepatitis B Vaccine in Homosexual MenHepatitis B Vaccine in Healthy Hospital EmployeesThe prophylaxis of hepatitis B infection 1 September 1982Volume 97, Issue 3Page: 451-451KeywordsHepatitis BHepatitis B virusHomosexualsSafetyVaccines Issue Published: 1 September 1982 PDF DownloadLoading ...