Key result
Ultrasound showed good agreement with 4D flow CMR for quantifying left ventricular direct flow (Ric 0.82; 95% CI 0.33-0.97) and residual volume (Ric 0.85; 95% CI 0.41-0.97).
Why the study?
Four-dimensional flow CMR is the reference technique for analyzing LV blood transport, but whether similar transport information from ultrasound is valid remained to be determined.
Does transthoracic echocardiography accurately quantify left ventricular blood flow transport compared to 4D flow CMR in patients and healthy volunteers?
Observational (n=7)
Does transthoracic echocardiography accurately quantify left ventricular blood flow transport compared to 4D flow CMR in patients and healthy volunteers?
Effect estimate: Ric 0.82 (DF) and 0.85 (RV) (95% CI 0.33-0.97 (DF) and 0.41-0.97 (RV))
Ultrasound is a suitable and accessible method for analyzing intraventricular flow transport in the clinical setting, showing good agreement with 4D flow CMR for direct flow and residual volume.
May support echo for accessible LV flow assessment; leaves open prospective validation before clinical adoption.
Four-dimensional flow cardiac magnetic resonance (CMR) is the reference technique for analyzing blood transport in the left ventricle (LV), but similar information can be obtained from ultrasound. We aimed to validate ultrasound-derived transport in a head-to-head comparison against 4D flow CMR. In five patients and two healthy volunteers, we obtained 2D + t and 3D + t (4D) flow fields in the LV using transthoracic echocardiography and CMR, respectively. We compartmentalized intraventricular blood flow into four fractions of end-diastolic volume: direct flow (DF), retained inflow (RI), delayed ejection flow (DEF) and residual volume (RV). Using ultrasound we also computed the properties of LV filling waves (percentage of LV penetration and percentage of LV volume carried by E/A waves) to determine their relationships with CMR transport. Agreement between both techniques for quantifying transport fractions was good for DF and RV ( R ic [95% confidence interval]: 0.82 [0.33, 0.97] and 0.85 [0.41, 0.97], respectively) and moderate for RI and DEF ( R ic = 0.47 [–0.29, 0.88] and 0.55 [–0.20, 0.90], respectively). Agreement between techniques to measure kinetic energy was variable. The amount of blood carried by the E-wave correlated with DF and RV ( R = 0.75 and R = 0.63, respectively). Therefore, ultrasound is a suitable method for expanding the analysis of intraventricular flow transport in the clinical setting.
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Postigo et al. (2022) reported an observational. Ultrasound (transthoracic echocardiography) vs. 4D flow cardiac magnetic resonance (CMR) was evaluated on Agreement between techniques for quantifying direct flow (DF) and residual volume (RV) transport fractions (Ric 0.82 (DF) and 0.85 (RV), 95% CI 0.33-0.97 (DF) and 0.41-0.97 (RV)). Ultrasound showed good agreement with 4D flow CMR for quantifying left ventricular direct flow (Ric 0.82; 95% CI 0.33-0.97) and residual volume (Ric 0.85; 95% CI 0.41-0.97).
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