Studies on Drug Toxicity in Chicks

SULFAQUINOXALINE is an anticoccidial agent. It has been used extensively in the poultry industry for the prevention and treatment of coccidiosis. Thorp et al. (1947); Delaplane and Milliff (1948); Peterson and Hymas (1950); Sadek et al. (1955); and others have reported on its use as a chemotherapeutic agent and on some toxic side effects. Delaplane and Milliff (1948); Peterson and Hymas (1950); and Sadek et al. (1955), attributed many symptoms and lesions to excessive dosage or prolonged administration. More recently sulfaquinoxaline has been associated with the hemorrhagic syndrome by Cover and co-workers (1955). This experiment was conducted to further investigate the effect of sulfaquinoxaline on the growing chick. MATERIALS AND METHODS Day old Lancaster chicks were used in this experiment. The chicks were housed in five-deck electrically heated batteries in lots of 25 with approximately equal sex distribution. Food and water were supplied ad libitum. Composition of the ration is …