The Relative Non-Toxicity of Diphenyl-p-Phenylenediamine (DPPD) to Chicks When Fed Continuously for 12 Weeks at the 1% Level

The technical data bulletin of the National Alfalfa Dehydrating and Milling Company reports toxicity studies with DPPD, using both hens and growing chickens.2 The bulletin reports studies on both chronic and acute effects, and it is concluded from the histo-pathological studies made that DPPD is non-toxic to chickens at the levels investigated. In acute-toxicity studies with growing chicks, the data given start with 100-gram White Leghorn chicks (no age given). The birds were fed a specified amount of DPPD daily in capsules, for a period of 98 days. Using feed consumption data from our own laboratory, it was estimated that the amount of DPPD given by capsule was equivalent to about 0.3% DPPD in the feed for the first 57 days and about 0.8% DPPD in the feed for the 57th to 98th day. The authors were interested in the possible toxic effects of feeding a 1% level of DPPD …