June 1, 1991Circulation
Intravenous nitroglycerin infusion inhibits cyclic blood flow responses caused by periodic platelet thrombus formation in stenosed canine coronary arteries.
Why the study?
Does intravenous nitroglycerin infusion reduce periodic platelet thrombus formation in a canine model of coronary artery stenosis?
Population
Canine model of coronary artery stenosis associated with cyclic reductions in coronary blood flow
Design
Preclinical
Follow-up
40-minute observation period
Authors
Discussion
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Member takes
Implication
May support antithrombotic role of nitroglycerin in coronary stenosis; hypothesis-generating in canine models, translation to humans unproven.
Structured PICO
Does intravenous nitroglycerin infusion reduce periodic platelet thrombus formation in a canine model of coronary artery stenosis?
P
Population
Canine model of coronary artery stenosis associated with cyclic reductions in coronary blood flow
I
Intervention
Continuous infusion of intravenous nitroglycerin (10-15 micrograms/kg/min, or 5 micrograms/kg/min after pretreatment with N-acetylcysteine 100 mg/kg during 30 minutes)
O
Outcome
Frequency of cyclic platelet thrombus formation per 40-minute observation periodsurrogate
Intravenous nitroglycerin inhibits platelet thrombus formation in vivo, an effect potentiated by reduced thiols, suggesting an antithrombotic mechanism for its benefit in acute coronary syndromes.
Cite This Study
Folts et al. (1991) studied this question.