Acute Renal Insufficiency During Treatment With Azathioprine

Fever, muscular pain, gastrointestinal symptoms, oliguria and severe reduction of renal function developed in a 49‐year‐old man, suffering from chronic glomerulonephritis, after 11 days of treatment with azathioprine, 3.4 mg/kg/day. During a later attempt at treatment with 1.1 mg/kg/day the same picture was reproduced after a few hours. The kidney damage was probably part of a hypersensitivity reaction to azathioprine. The patient later tolerated treatment with cyclophosphamide.