Key result
High levels of LogNT-proBNP were an independent predictor of all-cause death (HR 2.85; 95% CI 1.91-4.24; p<0.001) and cardiovascular death in a general population cohort.
Why the study?
Is elevated NT-proBNP associated with increased all-cause and cardiovascular mortality in a general population cohort?
Cohort (n=2,021)
Is elevated NT-proBNP associated with increased all-cause and cardiovascular mortality in a general population cohort?
Hazard Ratio: 2.85 (95% CI 1.91–4.24)
p-value: p=<0.001
Elevated NT-proBNP is an independent predictor of long-term all-cause and cardiovascular mortality in the general population.
May aid risk stratification in general populations; leaves open whether NT-proBNP-targeted therapy alters outcomes.
AIM: We investigated the relationship between NT-ProBNP and mortality in a general population-based cohort. METHODS & RESULTS: A total of 2021 out of 4650 participants from previously published HAPPY study were included. Mean follow-up was 84.5 ± 10.4 months. After adjusting for risk factors, high levels of LogNT-proBNP predicted all-cause death (HR: 3.23; 95% CI: 2.20-4.75; p < 0.001) and cardiovascular death (HR: 3.85; 95% CI: 2.37-6.26; p < 0.001). Regression analysis revealed that LogNT-proBNP was an independent predictor of all-cause death (HR: 2.85; 95% CI: 1.91-4.24; p < 0.001) and cardiovascular death (HR: 3.02; 95% CI: 1.84-4.95; p < 0.001). Conclusıon: Our study showed that in long term follow-up, NT-proBNP is associated with increased all-cause and cardiovascular mortality.
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Şimşek et al. (2018) conducted a cohort in General population (n=2,021). High levels of LogNT-proBNP was evaluated on All-cause death (HR 2.85, 95% CI 1.91-4.24, p=<0.001). High levels of LogNT-proBNP were an independent predictor of all-cause death (HR 2.85; 95% CI 1.91-4.24; p<0.001) and cardiovascular death in a general population cohort.
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