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Three simple steps were required to prepare the β-sulfonamide alcohol ligand (L*) from L-phenylalanine. Its titanium complex efficiently catalyzes the asymmetric addition of phenylacetylene (2) to aromatic aldehydes 1 to form enantiomerically pure propargyl alcohols 3. Ts=p-toluenesulfonyl, R=substituted phenyl or naphthyl group.
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Xu et al. (2003) studied this question.
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