Key result
In cardiomyopathic hamsters, altered Cx43 expression and phosphorylation at 20 weeks of age, along with interstitial fibrosis, contributed to an arrhythmogenic substrate.
Authors
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Identifies Cx43 alterations as arrhythmia substrate in cardiomyopathy models; leaves open translation to human disease.
Sato et al. (2007) studied Heart failure. Cardiomyopathy development (UM-X7.1 strain) vs. Control golden hamsters was evaluated on Cx43 expression and electrophysiological properties. In cardiomyopathic hamsters, altered Cx43 expression and phosphorylation at 20 weeks of age, along with interstitial fibrosis, contributed to an arrhythmogenic substrate.
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