Key result
Platelet inhibition in moderate to severe isolated blunt traumatic brain injury was associated with increased hospital mortality (adjusted OR 4.3) compared to no inhibition, while correction of inhibition normalized mortality.
Why the study?
Platelet dysfunction occurs after traumatic brain injury regardless of platelet inhibitor use, but the efficacy of platelet-mapping thromboelastography in predicting which patients benefit from platelet transfusion was unknown.
Does guideline-based platelet transfusion guided by PM-TEG improve hospital mortality in patients with moderate to severe isolated blunt traumatic brain injury and platelet dysfunction?
Cohort (n=69)
No
Does guideline-based platelet transfusion guided by PM-TEG improve hospital mortality in patients with moderate to severe isolated blunt traumatic brain injury and platelet dysfunction?
Odds Ratio: 4.3 (95% CI 1.01–18.43)
Absolute Event Rate: 41.4% vs 27.5%
p-value: p=0.0480
In patients with moderate to severe isolated blunt traumatic brain injury, uncorrected platelet inhibition is associated with increased mortality, whereas successful correction of platelet inhibition via guideline-based transfusion normalizes mortality risk to that of patients without baseline inhibition.
Platelet dysfunction has been demonstrated after traumatic brain injury (TBI) regardless of the use of platelet inhibitors. The purpose of this study was to determine the efficacy of a platelet-mapping thromboelastography (PM-TEG) in predicting TBI patients who would benefit from platelet transfusion. We hypothesized that adenosine diphosphate (ADP) and arachadonic acid (AA) inhibition in patients with TBI is associated with increased mortality and can be corrected with platelet transfusion. This is a retrospective review of patients admitted to a level 1 trauma center from January 2016 through September 2017 with moderate to severe blunt TBI (msTBI), defined by an initial Glasgow Coma Scale (GCS) ≤12 with intracranial hemorrhage. Patients received PM-TEG. Those with platelet dysfunction (ADP or AA inhibition ≥60%) received one unit of platelets followed by repeat PM-TEG, until inhibition <60% or three units of platelets. Cohorts were defined as patients initially without (NPI) and with (PI) inhibition and subdivided into those whose inhibition corrected (PI-C) versus those whose did not correct (PI-NC). From 69 patients with isolated blunt TBI, 40 (58%) presented with NPI, 29 (42%) with PI. Of those with PI, 16 (55%) were with PI-C and 13 (45%) with PI-NC. Platelet inhibition in msTBI patients undergoing guideline-based transfusion is associated with age and GCS and an increase in mortality. Platelet inhibition seems to have a more adverse effect on patients >55 years of age or with GCS <8. Correction of platelet inhibition normalized mortality to that of NPI.
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Sorah et al. (2022) conducted a cohort in Moderate to severe isolated blunt traumatic brain injury (n=69). Platelet inhibition vs. No platelet inhibition was evaluated on Hospital mortality from all causes (OR 4.3, 95% CI 1.01-18.43, p=0.0480). Platelet inhibition in moderate to severe isolated blunt traumatic brain injury was associated with increased hospital mortality (adjusted OR 4.3) compared to no inhibition, while correction of inhibition normalized mortality.
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