Population
Molecular models of PDZ-RhoGEF and RhoA
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether unique polar contacts can guide selective RhoA inhibitors in disease models.
The study identifies that polar contacts involving unique residues define the selectivity of PDZ-RhoGEF for RhoA over Cdc42.
Oleksy et al. (2006) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: