Key result
Polycystic ovary syndrome was not associated with significant differences in electrocardiographic patterns, including QTc max (445 vs 443 ms, P=0.70), compared to healthy matched controls.
Why the study?
Does polycystic ovary syndrome alter electrocardiographic patterns compared to healthy women?
Case-Control (n=100)
Does polycystic ovary syndrome alter electrocardiographic patterns compared to healthy women?
Despite hormonal and metabolic differences, women with polycystic ovary syndrome do not exhibit significant alterations in standard electrocardiographic repolarization parameters compared to healthy matched controls.
Reassures against routine ECG monitoring changes in PCOS; leaves open arrhythmia risk assessment in larger prospective studies.
OBJECTIVE: The aim of the present study was to investigate the potential alterations in electrocardiographic (ECG) pattern in patients with polycystic ovary syndrome (PCOS). PATIENTS: Fifty PCOS patients and 50 age- and body mass index-matched healthy women were studied. METHODS: We assessed hormonal and metabolic pattern, and performed ECG analysis for evaluating PQ interval, QRS duration, minimum and maximum QT interval corrected for heart rate (QT(c)min and QT(c)max, respectively), corrected QT dispersion (QT(c)d), corrected J point/T-wave interval (JTend(c)), corrected JTmax interval (JTmax(c)), and corrected Tmax-end interval (Tmax-end(c)). RESULTS: QT(c)min (399 +/- 21 vs. 396 +/- 25 ms, P = 0.51); QT(c) max (445 +/- 25 vs. 443 +/- 27 ms, P = 0.70); and QT(c)d (46 +/- 13 vs. 47 +/- 15 ms, P = 0.72); JTend(c) (337 +/- 14 vs. 336 +/- 16 ms(1/2), P = 0.74); and JTmax(c) (256 +/- 22 vs. 258 +/- 21 ms(1/2), P = 0.64); Tmax-end(c) (81 +/- 18 vs. 78 +/- 19 ms(1/2), P = 0.42) were not significantly different between PCOS and healthy women. CONCLUSION: Despite profound differences in hormonal and metabolic pattern, our data demonstrate no significant difference in ECG pattern in PCOS compared to healthy controls.
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Orio et al. (2007) conducted a case-control in Polycystic ovary syndrome (PCOS) (n=100). Polycystic ovary syndrome vs. Healthy women was evaluated on Maximum QT interval corrected for heart rate (QTc max) (p=0.70). Polycystic ovary syndrome was not associated with significant differences in electrocardiographic patterns, including QTc max (445 vs 443 ms, P=0.70), compared to healthy matched controls.
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