Key result
Beta-adrenoblockers with vasodilatory properties significantly reduce central aortic pressure, overcoming the insufficient impact of standard beta-blockers linked to peripheral vasoconstriction.
Why the study?
Do antihypertensive drugs, specifically beta-blockers with vasodilatory properties, improve aortic stiffness and central aortic pressure in arterial hypertension?
Do antihypertensive drugs, specifically beta-blockers with vasodilatory properties, improve aortic stiffness and central aortic pressure in arterial hypertension?
Beta-blockers with vasodilatory properties may be more effective at reducing central aortic pressure and modifying arterial stiffness in hypertension.
May support vasodilatory beta-blockers for central pressure reduction; leaves open outcome trials before practice change.
A plenty of trials confirm the importance of aortic wall stiffness evaluation during estimation of the cardiovascular risk and the need for novel drugs influencing this parameter. Most of hypotensive medications modify arterial wall siffness by one or another way. So the usage of drug combination might be more effective. Insufficient impact of betaadrenoblockers on central artrial pressure is linked to peripheral vasoconstriction. The drugs within this class having vasodilatory properties significantly reduce central aortic pressure.
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Shupenina et al. (2014) conducted a review in Arterial hypertension. Antihypertensive drugs was evaluated on Aortic stiffness and central aortic pressure. Beta-adrenoblockers with vasodilatory properties significantly reduce central aortic pressure, overcoming the insufficient impact of standard beta-blockers linked to peripheral vasoconstriction.
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