Key result
Maternal diabetes mellitus was not significantly associated with congenital heart disease in neonates, as CHD was present in 41.11% of offspring from both diabetic and non-diabetic mothers (p=0.535).
Why the study?
Congenital heart disease represents about one-third of major congenital anomalies and is common in infants of diabetic mothers, but its detected incidence is increasing globally with improved neonatal echocardiography facilities.
Does maternal diabetes mellitus increase the risk of congenital heart disease in neonates suspected of having CHD?
Cross-Sectional (n=90)
Yes
Does maternal diabetes mellitus increase the risk of congenital heart disease in neonates suspected of having CHD?
In a cohort of neonates suspected of having congenital heart disease, maternal diabetes mellitus was not significantly associated with a higher incidence of confirmed CHD compared to non-diabetic mothers.
Answers are grounded in this paper and cite their sources.
Maternal diabetes may not refine CHD confirmation among suspected neonates; leaves open its role in unselected pregnancies.
Background: Congenital heart disease (CHD) contributes about one-third of all major congenital anomalies in the world among the neonates, most common in infants of diabetic mothers but incidence is increasing all over the world due to establishing cardiac investigation facilities especially neonatal echocardiogram. Materials & Methods: A hospital-based cross-sectional study was done in two private hospitals in Dhaka from July ’19 to June ’20. A total of 90 neonates were included from nursery and neonatal intensive care units of both hospitals who were requested for echocardiography as suspected CHD. Results: In our study 52% mothers had diabetes mellitus (DM) during this conception and remains were normoglycemic. CHD present in 41.11% non-DM & DM mother’s offspring, there was no significant statistical difference among the groups (p=0.535). Gestational age and maternal coexisting diseases caused little impact on CHD in neonates (p <0.1). Regarding neonatal conditions only respiratory distress was significantly associated with CHD at p<0.05 level. Conclusions: Researcher according to our study diabetes mellitus does not contribute to CHD in neonates. Researcher can focus on other maternal comorbidities and other factors like respiratory distress and cyanosis after birth, which may contribute to CHD in neonates. J Bangladesh Coll Phys Surg 2023; 41: 27-32
No takes yet. Share an insight, caveat, or question.
Afrin et al. (2022) conducted a cross-sectional in Suspected congenital heart disease (n=90). Maternal diabetes mellitus vs. Non-diabetic mothers was evaluated on Presence of congenital heart disease (CHD) (p=0.535). Maternal diabetes mellitus was not significantly associated with congenital heart disease in neonates, as CHD was present in 41.11% of offspring from both diabetic and non-diabetic mothers (p=0.535).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: