Key result
Cardiac injury and cardiomyopathies were common in patients with COVID-19, with elevated troponin levels in 21.5% and mild, moderate, or severe left ventricular dysfunction in 17.1%, 11.9%, and 10% of patients, respectively.
Why the study?
Limited data were available on cardiac complications in patients with COVID-19 leading to severe outcomes during the COVID-19 pandemic.
Systematic Review (n=1,460)
Cardiac injury and cardiomyopathies are common in COVID-19 patients and are associated with significant left ventricular dysfunction and high mortality.
Supports cardiac monitoring in COVID-19; extends observational evidence on myocardial injury to guide risk stratification.
Background: Cardiomyopathies (CMPs) due to myocytes involvement are among the leading causes of sudden adolescent death and heart failure. During the COVID-19 pandemic, there are limited data available on cardiac complications in patients with COVID-19, leading to severe outcomes. Methods: We conducted a systematic search in Pubmed/Medline, Web of Science, and Embase databases up to August 2020, for all relevant studies about COVID-19 and CMPs. Results: A total of 29 articles with a total number of 1460 patients were included. Hypertension, diabetes, obesity, hyperlipidemia, and ischemic heart disease were the most reported comorbidities among patients with COVID-19 and cardiomyopathy. In the laboratory findings, 21.47% of patients had increased levels of troponin. Raised D-dimer levels were also reported in all of the patients. Echocardiographic results revealed mild, moderate, and severe Left Ventricular (LV) dysfunction present in 17.13, 11.87, and 10% of patients, respectively. Conclusions: Cardiac injury and CMPs were common conditions in patients with COVID-19. Therefore, it is suggested that cardiac damage be considered in managing patients with COVID-19.
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Omidi et al. (2021) conducted a systematic review in COVID-19 and Cardiomyopathy (n=1,460). COVID-19 was evaluated on Cardiomyopathy and cardiac injury manifestations (e.g., LV dysfunction, elevated troponin). Cardiac injury and cardiomyopathies were common in patients with COVID-19, with elevated troponin levels in 21.5% and mild, moderate, or severe left ventricular dysfunction in 17.1%, 11.9%, and 10% of patients, respectively.
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