Key result
In-hospital levels of selected circulating microRNAs were not significant predictors of left ventricular remodeling at 6 months post-myocardial infarction.
Why the study?
Biochemical and molecular regulation of heart tissue response to ischemic injury remains incompletely understood, and biomarkers are needed to predict left ventricular remodeling after myocardial infarction.
Do circulating microRNAs measured in the acute phase of myocardial infarction predict left ventricular remodeling?
Observational (n=80)
Do circulating microRNAs measured in the acute phase of myocardial infarction predict left ventricular remodeling?
Circulating levels of selected miRNAs in the acute phase of myocardial infarction do not appear to predict subsequent left ventricular remodeling at 6 months.
Acute-phase microRNA levels should not inform post-MI remodeling prognosis; leaves open utility pending larger prospective studies.
Background and Objectives: Biochemical and molecular regulation of both adaptive and pathological responses of heart tissue to ischemic injury is widely investigated. However, it is still not fully understood. Several biomarkers are tested as predictors of left ventricle (LV) remodeling after myocardial infarction (MI). The aim of this study was to assess the relationship between selected microRNAs (miRNAs) and LV function and morphology in patients after MI. Materials and Methods: Selected miRNAs related to heart failure were assessed in the acute phase of MI: miR-150-3p, miR-21-5p, miR-19b-3p, miR-155-5p, miR-22-5p. Echocardiography with 3D imaging was performed at baseline and after 6 months. Remodeling was defined as >20% increase in LV end-diastolic volume, whereas reverse remodeling was defined as >10% reduction in LV end-systolic volume. Results: Eighty patients entered the registry. Remodeling occurred in 26% and reverse remodeling was reported in 51% of patients. In the presented study, none of the analyzed miRNAs were found to be a significant LV remodeling predictor. The observed correlations between miRNAs and other circulating biomarkers of myocardial remodeling were relatively weak. Conclusions: Our analysis does not demonstrate an association between the analyzed miRNAs and LV remodeling in patients with MI.
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Węgiel et al. (2024) conducted an observational in Myocardial Infarction (n=80). Circulating MicroRNAs (miR-150-3p, miR-21-5p, miR-19b-3p, miR-155-5p, miR-22-5p) was evaluated on Left ventricular remodeling (>20% increase in LV end-diastolic volume). In-hospital levels of selected circulating microRNAs were not significant predictors of left ventricular remodeling at 6 months post-myocardial infarction.
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