January 1, 2012International Journal of Medical SciencesOpen Access

MicroRNA 21 Inhibits Left Ventricular Remodeling in the Early Phase of Rat Model with Ischemia-reperfusion Injury by Suppressing Cell Apoptosis

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Why the study?

Does Ad-miR-21 improve left ventricular remodeling and decrease apoptosis in a rat model of ischemia-reperfusion injury?

Population

10-week-old male Sprague-Dawley rats with ischemia-reperfusion injury induced by 60-min left anterior…

Comparison

Adenovirus expressing miR-21 delivered in vivo 3… vs Control adenovirus expressing GFP and sham…

Design

Preclinical, Rats were randomly divided into three groups, counted using light…

Follow-up

1 week

Authors

YQYanjun QinHebei Medical University YYYueqing YuHebei Medical University XBXiao‐Hua BianChinese Academy of Sciences

Discussion

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Implication

Hypothesis-generating for miR-21 in rodent I/R injury; leaves open translation to clinical cardioprotection.

Structured PICO

Does Ad-miR-21 improve left ventricular remodeling and decrease apoptosis in a rat model of ischemia-reperfusion injury?

Population

10-week-old male Sprague-Dawley rats (250-300 g) with ischemia-reperfusion (I/R) injury induced by 60-min left anterior descending coronary artery occlusion, and primary neonatal rat cardiac ventricular myocytes subjected to hypoxia/reoxygenation.

Intervention

Adenovirus expressing miR-21 (Ad-miR-21) delivered in vivo 3 days before I/R; pre-miR-21 delivered in vitro.

Comparator

Control adenovirus expressing GFP (Ad-GFP) and sham surgery in vivo; vehicle control and miR-21 inhibitor (LNA-anti-miR-21) in vitro.

Outcome

Left ventricular remodeling parameters including LV dimensions, myocardial infarct size, LV/BW ratio, collagen type I and III content, and cell apoptosis at 1 week after I/R.surrogate

Overexpression of miR-21 protects against ischemia-reperfusion injury by reducing myocardial infarct size, decreasing apoptosis, and attenuating left ventricular remodeling in a rat model.

Cite This Study

Qin et al. (2012) studied this question.

synapsesocial.com/papers/6a983e0b713b4e110fe35a53 https://doi.org/10.7150/ijms.4514

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MicroRNA 21 Inhibits Left Ventricular Remodeling in the Early Phase of Rat Model with Ischemia-reperfusion Injury by Suppressing Cell Apoptosis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

MicroRNA 21 Inhibits Left Ventricular Remodeling in the Early Phase of Rat Model with Ischemia-reperfusion Injury by Suppressing Cell Apoptosis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider