Key result
Serum cardiac troponin T was the only independent cardiac marker predicting all-cause mortality in hemodialysis patients (HR 1.04; 95% CI 1.01-1.07; p<0.01).
Why the study?
Does serum cardiac troponin T predict mortality and correlate with nutritional status in hemodialysis patients?
Cohort (n=118)
Does serum cardiac troponin T predict mortality and correlate with nutritional status in hemodialysis patients?
In hemodialysis patients, elevated cardiac troponin T is associated with underweight status and serves as an independent predictor of all-cause mortality.
Answers are grounded in this paper and cite their sources.
Troponin T may aid mortality risk stratification in hemodialysis; leaves open nutritional links and need for prospective validation.
BACKGROUND: Serum cardiac troponin T (cTnT) is a valuable marker of ischemic heart disease (IHD) and left ventricular hypertrophy, as well as a mortality predictor in hemodialysis populations. We compared the value of cTnT, creatinine kinase (CK)-MB mass and myoglobin as mortality predictors in our hemodialysis patients and evaluated their relation to nutritional status. METHODS: A total of 118 hemodialysis patients were prospectively studied from January 2004 to April 2013. Clinical and laboratory evaluations during the 12-month baseline period included the history of IHD, signs of left ventricular hypertrophy (LVH), Kt/V and serum cardiac markers together with the percentage of body fat (%fat), mid-arm circumference (MAC), mid-arm muscle circumference (MAMC), triceps skinfold (TSF) and BMI. RESULTS: Underweight patients had significantly higher cTnT values (Mann-Whitney, p<0.05). Correlation analysis (Spearman) showed an inverse association between cTnT and TSF (ρ=-0.22, p<0.05), as well as between CK-MB mass and TSF (ρ=-0.26, p<0.01). In men cTnT also correlated inversely with %fat (ρ=-0.27, p<0.05) and BMI (ρ=-0.33, p<0.05). In addition, myoglobin was correlated significantly with MAC, MAMC and albumin. Among cardiac markers cTnT was the only independent variable predicting mortality (Multivariate Cox regression, HR=1.04 CI (1.01-1.07); p<0.01; measurement units 0.01 μg/L). CONCLUSION: Troponin T and CK-MB mass were significantly elevated in the underweight patient group. Troponin T was the only independent cardiac marker predictor of all cause mortality in our hemodialysis patients.
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Stošović et al. (2014) conducted a cohort in hemodialysis (n=118). Serum cardiac troponin T (cTnT) was evaluated on all cause mortality (HR 1.04, 95% CI 1.01-1.07, p=<0.01). Serum cardiac troponin T was the only independent cardiac marker predicting all-cause mortality in hemodialysis patients (HR 1.04; 95% CI 1.01-1.07; p<0.01).
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