Key result
Elevated pre-dialysis cTnT is linked to significantly higher 12-month cardiac events.
Why the study?
The prognostic value of a new sensitive cardiac troponin T assay compared with troponin I and CK-MB in end-stage renal failure patients without acute myocardial infarction was unclear.
Does elevated cardiac troponin T predict 12-month cardiac events in asymptomatic patients with end-stage renal disease on hemodialysis?
Cohort (n=100)
Yes
Does elevated cardiac troponin T predict 12-month cardiac events in asymptomatic patients with end-stage renal disease on hemodialysis?
Absolute Event Rate: 0.13% vs 0.05%
p-value: p=≤0.01
Elevated cardiac troponin T is a useful prognostic marker for predicting cardiovascular events in asymptomatic hemodialysis patients.
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Troponin T may aid risk stratification in asymptomatic hemodialysis patients; leaves open whether routine use improves outcomes.
Osman et al. (2024) conducted a cohort in End-stage renal disease (ESRD) on hemodialysis (n=100). Elevated pre-dialysis Cardiac Troponin T (cTnT) vs. Normal cTnT levels / other cardiac markers was evaluated on 12-month cardiac events (admission for unstable angina, acute myocardial infarction, or sudden death) (p=≤0.01). Median pre-dialysis cardiac troponin T levels were significantly higher in patients who experienced 12-month cardiac events compared to those who did not (0.13 vs 0.05 μg/l, p≤0.01).
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