Key result
Total arch replacement for type A acute aortic dissection was associated with a higher risk of operative death compared to hemiarch replacement (33% vs 15%; OR 8.8, 95% CI 1.39-15, P=0.021).
Why the study?
Does total arch replacement compared to hemiarch replacement improve outcomes in patients with type A acute aortic dissection?
Cohort (n=92)
No
Does total arch replacement compared to hemiarch replacement improve outcomes in patients with type A acute aortic dissection?
Odds Ratio: 8.8 (95% CI 1.39–15)
Absolute Event Rate: 33% vs 15%
p-value: p=0.021
Hemiarch replacement can be performed more safely than total arch replacement in type A acute aortic dissection, with no difference in distal aortic reoperation rates.
Total arch replacement was associated with higher operative mortality; leaves open optimal arch extent in type A dissection pending randomized trials.
We retrospectively evaluated early and intermediate outcomes of aortic arch surgery in patients with type A acute aortic dissection (AAD), investigating the effect of arch surgery extension on postoperative results. From January 2006 through July 2013, 201 patients with type A AAD underwent urgent corrective surgery at our institution. Of the 92 patients chosen for this study, 59 underwent hemiarch replacement (hemiarch group), and 33 underwent total arch replacement (total arch group) in conjunction with ascending aorta replacement. The operative mortality rate was 22%. Total arch replacement was associated with a 33% risk of operative death, versus 15% for hemiarch (P=0.044). Multivariable analysis found these independent predictors of operative death: age (odds ratio [OR]=1.13/yr; 95% confidence interval [CI], 1.04–1.23; P=0.002), body mass index >30 kg/m2 (OR=9.9; 95% CI, 1.28–19; P=0.028), postoperative low cardiac output (OR=10.6; 95% CI, 1.18–25; P=0.035), and total arch replacement (OR=8.8; 95% CI, 1.39–15; P=0.021) The mean overall 5-year survival rate was 59.3% ± 5.5%, and mean 5-year freedom from distal reintervention was 95.4% ± 3.2% (P=NS). In type A AAD, aortic arch surgery is still associated with high operative mortality rates; hemiarch replacement can be performed more safely than total arch replacement. Rates of distal aortic reoperation were not different between the 2 surgical strategies.
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Lio et al. (2016) conducted a cohort in Type A acute aortic dissection (n=92). Total arch replacement vs. Hemiarch replacement was evaluated on Operative death (OR 8.8, 95% CI 1.39-15, p=0.021). Total arch replacement for type A acute aortic dissection was associated with a higher risk of operative death compared to hemiarch replacement (33% vs 15%; OR 8.8, 95% CI 1.39-15, P=0.021).
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