Na+,K+-ATPase concentration in rodent and human heart and skeletal muscle: apparent relation to muscle performance
Population
Rats, hamsters, and 15 human subjects (6 with mean LVEF 68%, 9 with mean LVEF 29%)
Comparison
Swim training, cardiomyopathy, heart… vs Untrained/normal/preserved LVEF counterparts
Design
Preclinical
Follow-up
6 weeks (for rat swim training)
Authors
Discussion
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Member takes
Implication
Association with LVEF in human myocardium extends animal data; leaves open causal role and therapeutic targeting in HF.
Structured PICO
P
Population
Rats, hamsters, and 15 human subjects (6 with mean LVEF 68%, 9 with mean LVEF 29%)
I
Intervention
Swim training (rats), cardiomyopathy (hamsters), heart failure/reduced LVEF (humans)
C
Comparator
Untrained/normal/preserved LVEF counterparts
O
Outcome
Na+,K+-ATPase concentration in heart ventricular musclessurrogate
Na+,K+-ATPase concentration in heart ventricular muscle correlates with muscle performance and is significantly reduced in heart failure.
Cite This Study
Kjeldsen et al. (1988) studied this question.